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More:Metal Gear Solid 4: Guns Of The Patriots: Combat

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Shoot from inside a dumpster

There are dumpsters throughout the game which you can use to hide. Move in front of them and press Triangle when the prompt appears. Once inside, if you have a handgun, for example The Operator, you can hold L1 to lift up the lid of the dumpster and aim your gun from inside.

Throw grenades underhanded

Lightly hold L1 (default [Aim]) instead of holding it down completely while throwing a grenade.

Defeating Vamp

In the first part of the battle against Vamp, after you get his health low enough he falls down. As he gets up, grab him in a CQC hold and inject him with the syringe that you obtained earlier. This will disable his Nanites and make him mortal.

You do not have to deplete Vamp's health before CQC grabbing him. Hide and sneak up behind him for a CQC.

Instead of depleting his life, use a tranquilizer gun and shoot his head. He will fall down, immediately giving you the chance for the CQC.

Keeping Meryl safe

While fighting Psycho Mantis, CQC Meryl and inject her with the syringe to take her safely out of the fight. Note: Mantis might take control of her again after awhile.

Easy Gekko kill

When you in the basement lab at Shadow Moses, when the Gekko appears, send the Mk II to the electric console to the right of the elevator. Note: This is the same console that was destroyed with the rocket in the original Metal Gear Solid. Use the Mk II to reactivate the electric floor and destroy the Gecko.

Bypassing Gekkos

Shoot five tranquilizer rounds into the legs of a Gekko. It will collapse and thrash around on the floor. You can walk past without being spotted while that is happening.

Easy hold-ups

Have you tranquilizer gun ready and fire at the target. Get close the sleeping target and go into your crouch position. An icon should appear to wake the target up. Press [Action] to wake your target. When he or she is about to wake up, position yourself at either side or the back of the target. Aim your gun and Snake should hold-up the target. This is an easy way to do CQC and knife kills if you want to get the Assassin's Creed emblem and costume.

Cleared areas

Clear an area of all enemies in Act 1 or Act 2. All the allied soldiers will begin to cheer. No additional enemies will respawn in those area if you return.