The Oregon Trail 2 (PC)
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Go to a livery stable and buy four to five oxen. Then,
go to trade and find someone who will trade money for your oxen.
Trade the oxen for as much money as possible, but more than what
you paid for them. Keep in mind that oxen differ in price depending
on what location you are in. Keep trading the oxen for more money
until the desired amount of money is received.
To catch fish, rest by a river, stream, or lake.
If you are a trail guide, be a pastor. It will keep
your morale high and you can trade sets of clothing at $10 profit
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If you choose the option to become a doctor at the
beginning of the game, the people in your party will most likely
heal faster when they get sick.
Strategy guides from GameFAQs